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LM11A-31 dihydrochloride

Name: LM11A-31 dihydrochloride
Brand: TargetMol
SKU: T11861
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11861Cas No. 1243259-19-9

LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist.

LM11A-31 dihydrochloride

🥰Excellent

Purity: 99.9%

Catalog No. T11861Cas No. 1243259-19-9

Pack Size	Price	Availability
25 mg	$48	In Stock
50 mg	$67	In Stock
100 mg	$88	In Stock
500 mg	$220	In Stock

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Batch Information

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Purity:99.9%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist.
In vivo	LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice[2].?LM11A-31 (oral gavage;?50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity[1].

Chemical Properties

Molecular Weight	316.27
Formula	C₁₂H₂₇Cl₂N₃O₂
Cas No.	1243259-19-9
Smiles	Cl.Cl.CC[C@H](C)[C@H](N)C(=O)NCCN1CCOCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 125 mg/mL (395.23 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.1619 mL	15.8093 mL	31.6186 mL	158.0928 mL
5 mM	0.6324 mL	3.1619 mL	6.3237 mL	31.6186 mL
10 mM	0.3162 mL	1.5809 mL	3.1619 mL	15.8093 mL
20 mM	0.1581 mL	0.7905 mL	1.5809 mL	7.9046 mL
50 mM	0.0632 mL	0.3162 mL	0.6324 mL	3.1619 mL
100 mM	0.0316 mL	0.1581 mL	0.3162 mL	1.5809 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc